AGAP2-AS1 was demonstrated as an oncogene in several cancers, including glioblastoma (GBM). However, the biological mechanisms of AGAP2-AS1 in GBM progression are still unclear. Herein, we found that AGAP2-AS1 expression was up-regulated in GBM tissues and cells. High AGAP2-AS1 expression may predict a poor prognosis in GBM patients.

The gene AGAP2-AS1 may have Genomic and Proteomic products available from Sigma-Aldrich.

FGFR1 was targeted by miR-497 in CRC cells Furthermore, dual luciferase reporter assay showed that overexpression of AGAP2-AS1 blocked the inhibition AGAP2-AS1 promotes CCA cell proliferation in vitroandvivo.(A-B)CCK-8 assay was performed to determine the proliferation of HUCCT1 and RBE cells with si … Interestingly, AGAP2‐AS1 sponges miR‐4,668‐3p to release SRSF1 in CRC. Furthermore, in the rescue functional assay, miR‐4,668‐3p down‐regulation exacerbated the malignant behaviors of AGAP2‐AS1‐depleted CRC cells, whereas such effects were further … SP1-induced lncRNA AGAP2-AS1 expression promotes chemoresistance of breast cancer by epigenetic regulation of MyD88 Symbol: AGAP2-AS1: Name: AGAP2 antisense RNA 1: Type: other: Synonyms: AGAP2 antisense RNA 1, AGAP2-AS1, LOC100130776, PNS, PUNISHER: Species: Human (AGAP2-AS1 EG The gene AGAP2-AS1 may have Genomic and Proteomic products available from Sigma-Aldrich. 2020-06-05 Complete information for SATB2-AS1 gene (RNA Gene), SATB2 Antisense RNA 1, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human Gene Compendium AGAP2-AS1 promoted glioma cell proliferation by sponging miR-15a/b-5p to upregulate the expression of HDGF; AGAP2-AS1 was upregulated and transcriptionally induced by SP1 in breast cancer..ChIP assays showed that AGAP2-AS1-bound CBP increased the enrichment of H3K27ac at the promoter region of MyD88, thus resulting in the upregulation of MyD88. Complete information for AGAP2-AS1 gene (RNA Gene), AGAP2 Antisense RNA 1, including: function, proteins, disorders, pathways, orthologs, and expression.

Methods Tissue samples and cell lines Fifty paired GC and adjacent nontumor AGAP2-AS1 inhibited cell migration, invasion and proliferation in vitro. AGAP2-AS1 suppressed tumor growth in vivo. Mechanistically, AGAP2-AS1 inhibited cell metastasis and proliferation by AGAP2-AS1, which is transcribed from a gene located on 12q14.1 and is 1567 nt in length, has been found to be overexpressed in human cancers. In non-small cell lung cancer (NSCLC), an increased expression of AGAP2-AS1 regulated the transcription of downstream targets by interacting with epigenetic proteins [ 13 ]. Besides, lncRNA AGAP2-AS1 could bind to miR-195-5p which targeted PDLIM5 and subsequently downregulated its expression, ultimately impeding the progression of prostate cancer. Additionally, lncRNA AGAP2-AS1 inhibition led to an up-regulated expression of miR-195-5p and down-regulated PDLIM5 expression, resulting in delayed tumor growth in vivo. Mechanistically, AGAP2-AS1 is associated with HuR, and the AGAP2-AS1–HuR complex could directly bind to the CPT1, increasing its expression via improving RNA stability.

Your search resulted in multiple matches. Please select a position: UCSC Genes AGAP2-AS1 (uc001sps.4) at chr12:58120023-58122139 - Homo sapiens AGAP2 antisense RNA 1 (AGAP2-AS1), non-coding RNA.

(B) AGAP2-AS1 decreased in OC tissues compared to ovarian borderline tumors (P < 0.05, Student's t-test). AGAP2-AS1 demonstrated higher expression in tumor tissues compared with normal tissues (P<0.001; Fig. 1A). Additionally, the expression of AGAP2-AS1 was analyzed in 72 pairs of ccRCC tissues and non-cancerous adjacent tissues using Wilcoxon singed-rank test.

AGAP2-AS1 demonstrated higher expression in tumor tissues compared with normal tissues (P<0.001; Fig. 1A). Additionally, the expression of AGAP2-AS1 was analyzed in 72 pairs of ccRCC tissues and non-cancerous adjacent tissues using Wilcoxon singed-rank test.

However, the role and mechanism of AGAP2-AS1 in papillary thyroid carcinoma (PTC) remain unclear. Thus, in this study, we aimed to explore the role of AGAP2-AS1 in PTC. Our results showed that AGAP2-AS1 was significantly upregulated in PTC tissues. Knockdown of AGAP2-AS1 inhibited the proliferation AGAP2-AS1 inhibits CCA cell proliferation, colony formation, and promotes apoptosis. In addition, we also studied the molecular mechanism of AGAP2-AS1 in CCA cells and found potential targets. Your search resulted in multiple matches. Please select a position: UCSC Genes AGAP2-AS1 (uc001sps.4) at chr12:58120023-58122139 - Homo sapiens AGAP2 antisense RNA 1 (AGAP2-AS1), non-coding RNA. Complete information for SATB2-AS1 gene (RNA Gene), SATB2 Antisense RNA 1, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human Gene Compendium Cancer Management and Research (2020-07-01) .

13 … 2021-01-01 AGAP2-AS1 upregulates the MMP2 expression, we first analyzed the cellular localization of AGAP2-AS1 using immunofluorescence. As shown in Figure 3A, AGAP2-AS1 was localized mainly in the cytoplasm in TPC1 and K1 cells. To investigate whether AGAP2-AS1 may SP1 induced AGAP2-AS1 plays an important role in tumorigenesis. AGAP2-AS1 knockdown signicantly inhibited proliferation and caused apoptosis in CCA cells. In addition, we demonstrated that AGAP2-AS1 promotes the proliferation of CCA. Conclusions: We conclude that the long non-coding RNA AGAP2-AS1 plays a role in promoting the proliferation of AGAP2-AS1 levels and clinicopathological features. Additionally, we investigated the functional impact of AGAP2-AS1 on tumor migration, invasion and proliferation during EOC progression through a series of in vitro and in vivo assays. Moreover, we also explored the molecular events that occurred AGAP2-AS1 was up-regulated and associated with poor prognosis in GBM. Knockdown of AGAP2 -AS1 suppressed proliferation and invasion, and facilitated apoptosis in GBM cells .
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4, ANRIL (CDKN2B antisense 9 Mar 2017 Additional file 1: Table S1. of Long noncoding AGAP2-AS1 is activated by SP1 and promotes cell proliferation and invasion in gastric cancer. 23 Mar 2020 AGAP2-AS1 promoted CRC cell proliferation and inhibited apoptosis.

In addition, we demonstrated that AGAP2-AS1 promotes the proliferation of CCA. AGAP2-AS1 and miR-497 in Ago2 complex, indicating that AGAP2-AS1 could directly bind to miR-497 (Figure 5D). These results suggest that AGAP2-AS1 interacts with miR-497. FGFR1 was targeted by miR-497 in CRC cells Furthermore, dual luciferase reporter assay showed that overexpression of AGAP2-AS1 blocked the inhibition Symbol: AGAP2-AS1: Name: AGAP2 antisense RNA 1: Type: other: Synonyms: AGAP2 antisense RNA 1, AGAP2-AS1, LOC100130776, PNS, PUNISHER: Species: Human (AGAP2-AS1 EG Long non-coding RNA (lncRNA) AGAP2-AS1 acts as an oncogene in several types of cancers.
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-4.29091, 0.00002, 0.00134, ASMTL-AS1, antisense, 1401769, 1414028, X 0.25865, 0.79591, 0.91497, AGAP2-AS1, antisense, 57726271, 57728356, 12.

Long non-coding RNA (lncRNA) AGAP2-AS1 acts as an oncogene in several types of cancers. However, the role and mechanism of AGAP2-AS1 in papillary thyroid carcinoma (PTC) remain unclear.