Salinomycin is the key compound in the pharmaceutical company Verastem's efforts to produce an anti-cancer-stem-cell drug. Use in agriculture. Salinomycin is used in chicken feed as a coccidiostat. Biosynthesis

This information is only displayed if the substance is well-defined, its identity is not claimed confidential and there is sufficient information available in ECHA’s databases for ECHA’s algorithms to generate a molecular structure. More help available here. EC / List no.: 258-290-1. CAS no.: 53003-10-4. Mol. formula: C42H70O11

The polyether ionophore salinomycin has recently gained attention due to its exceptional ability to selectively reduce the proportion of cancer stem cells within a number of cancer cell lines. Efficient single step strategies for the preparation of hydroxamic acid hybrids of this compound varying in N- and O-alkylation are presented. The parent hydroxamic acid, salinomycin-NHOH, forms both Structure, properties, spectra, suppliers and links for: Salinomycin sodium. Salinomycin with antibacterial and anticoccidial activities is a commercial polyether polyketide widely used in animal husbandry as a food additive. Malonyl-CoA (MCoA), methylmalonyl-CoA (MMCoA), and ethylmalonyl-CoA (EMCoA) are used as extension units in its biosynthesis.

View information & documentation regarding Name Cas(55721-31-8), Salinomycin sodium salt-Aladdin, ,Cation ionophore. Chemical Structure. Molecular Weight. Drug & Food Interactions. Target Sequences. Pharmaco-omics.

The thesis title is 'On the Breast Cancer Stem Cell Selectivity of Salinomycin and its Structural Analogues'. During the PhD study, I mainly focused on the effect of

Kong, M. This post Cell Here is my blog :: essay structure Ericka. Hi there friends Growing evidence suggests that salinomycin is able to kill different types of perceived as correct at that time; mediation through the anatomical structure. 30 mars 2021 — molecule model and chemical formula. Organic chemical compound.

Salinomycin Na (CAS 55721-31-8) is a polyether ionophore with antibiotic and Focus Biomolecules supplier, chemical structure of Salinomycin Na | Cancer

1 Treatment of 5 mg For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from PDBe, to allow us to map Pfam domains onto UniProt three-dimensional structures.The table below shows the sequences and Pfam domains that correspond to this structure. To the best of our knowledge until now no information on the ability of salinomycin to form complexes with Cd(II), Pb(II) and Hg(II) has been published. In the present paper we report for the first time the preparation and the structure characterization of salinomycin complexes with ions of … 2011-09-09 Search results for salinomycin751005300310411 at Sigma-Aldrich. Compare Products: Select up to 4 products. *Please select more than one item to compare chemBlink provides information on suppliers of Salinomycin (CAS # 53003-10-4) If submitting your inquiry to a single supplier, click Inquire for this suplier. If submitting your inquiry to multiple suppliers, . Global Salinomycin Premix Market Research Report 2018 Opportunities, Size, Cost Structure, Service Provider, Segmentation, Shares, Forecast to 2023 Aladdin offers a number of Salinomycin sodium salt, products.

2 Product Results. | Match Criteria: Product Name, Property, Description. Empirical Formula (Hill Notation): C42H70O11. Molecular Weight: 751.00. CAS Number: 53003-10-4. S4526.
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To visualize cellular uptake and subcellular localization of salinomycin, we sought a fluorescent conjugate that was functionally equivalent to the native structure.

Borgström, Björn et al.
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Abstract The ionophore salinomycin has attracted attention for its exceptional ability to selectively reduce the proportion of cells with stem‐like properties in cancer cell populations of varying

Name. Salinomycin. Synonyms. (2R)-2- ( (5S)-6- {5- [ (10S,12R)-2- ( (6S,5R)-5-Ethyl-5-hydroxy-6-methylperhydro-2H-pyran-2-yl)-15-hydroxy-2,10,12-trimethyl-1,6,8-trioxadispiro [4.1.5.3]pentadec-13-en-9-yl] (1S,2S,3S,5R)-2-hydroxy-1,3-dimethyl-4-oxoheptyl}-5-methylperhydro-2H-pyran-2-yl)butanoic acid. Molecular Structure. Synthetic strategies for modification of each of the directly accessible functional groups of salinomycin are presented and the resulting library of analogues was investigated to establish structure–activity relationships, both with respect to cytotoxicity and phenotype selectivity in breast cancer cells. 20-O-Acylated derivatives stand out by exhibiting both improved selectivity and activity.